VHL Ligand 14

• CAT Number: I040021
• CAS Number: 2010986-87-3
• Molecular Formula: C25H34N4O4S
• Molecular Weight: 486.63
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C25H34N4O4S/c1-14(17-7-9-18(10-8-17)21-15(2)26-13-34-21)27-23(32)20-11-19(31)12-29(20)24(33)22(25(4,5)6)28-16(3)30/h7-10,13-14,19-20,22,31H,11-12H2,1-6H3,(H,27,32)(H,28,30)/t14-,19+,20-,22+/m0/s1
• InChIKey: JAHUHEDUDMTTTF-COWZOJLOSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C)O

VHL Ligand 14 (Cat No.: I040021) is a synthetic small molecule designed to selectively bind the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. It is commonly used in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted protein degradation by recruiting specific proteins to the ubiquitin-proteasome system. VHL Ligand 14 plays a critical role in drug discovery and chemical biology, particularly for degrading disease-associated proteins. Its high affinity and specificity for VHL make it a valuable tool in designing next-generation therapeutic agents.

Reference

[1]. Hu J, et al., Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). J Med Chem. 2019 Feb 14;62(3):1420-1442.
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