For research use only. Not for therapeutic Use.
Vibunazole is a new antifungal azole.
Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1].
The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1].
| Catalog Number | R032940 |
| CAS Number | 80456-55-9 |
| Synonyms | 1-(4-chlorophenoxy)-3,3-dimethyl-2-(1,2,4-triazol-1-ylmethyl)butan-2-ol |
| Molecular Formula | C15H20ClN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H20ClN3O2/c1-14(2,3)15(20,8-19-11-17-10-18-19)9-21-13-6-4-12(16)5-7-13/h4-7,10-11,20H,8-9H2,1-3H3 |
| InChIKey | OCQPZTCGZAFWSG-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(CN1C=NC=N1)(COC2=CC=C(C=C2)Cl)O |
| Reference | [1]. Hoeprich PD, et al. Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis. Eur J Clin Microbiol. 1985 Aug;4(4):400-3. |
