For research use only. Not for therapeutic Use.
Vicagrel（Cat No.:I010026） is an acetate derivative of Clopidogrel, a P2Y12 platelet inhibitor. It has the potential to be used in the treatment of thrombosis, a condition characterized by abnormal blood clot formation in blood vessels. As a P2Y12 inhibitor, Vicagrel helps prevent platelet aggregation and subsequent clot formation. By inhibiting the activation of platelets, it can reduce the risk of thrombotic events, such as heart attacks or strokes. Vicagrel’s acetate modification aims to enhance its pharmacokinetic properties and therapeutic efficacy in comparison to Clopidogrel.
| Catalog Number | I010026 |
| CAS Number | 1314081-53-2 |
| Synonyms | Vicagrel; Clopidogrel;methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate |
| Molecular Formula | C18H18ClNO4S |
| Purity | ≥95% |
| Target | P2Y Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | methyl (2S)-2-(2-acetyloxy-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate |
| InChI | InChI=1S/C18H18ClNO4S/c1-11(21)24-16-9-12-10-20(8-7-15(12)25-16)17(18(22)23-2)13-5-3-4-6-14(13)19/h3-6,9,17H,7-8,10H2,1-2H3/t17-/m0/s1 |
| InChIKey | GNHHCBSBCDGWND-KRWDZBQOSA-N |
| SMILES | CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3Cl)C(=O)OC |
| Reference | </br>1:Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel. Qiu ZX, Gao WC, Dai Y, Zhou SF, Zhao J, Lu Y, Chen XJ, Li N.Front Pharmacol. 2016 Oct 7;7:366. eCollection 2016. PMID: 27774067 Free PMC Article</br>2:Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel. Qiu Z, Li N, Song L, Lu Y, Jing J, Parekha HS, Gao W, Tian F, Wang X, Ren S, Chen X.Pharm Res. 2014 Jan;31(1):238-51. doi: 10.1007/s11095-013-1158-5. Epub 2013 Sep 14. PMID: 24037619 </br>3:Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs. Qiu Z, Li N, Wang X, Tian F, Liu Q, Song L, Fan Z, Lu Y, Chen X.J Pharm Sci. 2013 Feb;102(2):741-9. doi: 10.1002/jps.23394. Epub 2012 Nov 28. PMID: 23192851 </br>4:Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. Shan J, Zhang B, Zhu Y, Jiao B, Zheng W, Qi X, Gong Y, Yuan F, Lv F, Sun H.J Med Chem. 2012 Apr 12;55(7):3342-52. doi: 10.1021/jm300038c. Epub 2012 Apr 2. PMID: 22428882 |
