Vildagliptin

• CAT Number: A000934
• CAS Number: 274901-16-5
• Molecular Formula: C₁₇H₂₅N₃O₂
• Molecular Weight: 303.40
• Purity: ≥95%
• Target: DPP-4
• Solubility: >12.1mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
• InChI: InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
• InChIKey: SYOKIDBDQMKNDQ-XWTIBIIYSA-N
• SMILES: C1C[C@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N

Vildagliptin（Cat No.:A000934）is an oral antidiabetic agent that inhibits dipeptidyl peptidase-4 (DPP-4), an enzyme responsible for breaking down incretin hormones. By inhibiting DPP-4, vildagliptin increases the levels of incretins such as GLP-1 and GIP, which enhance insulin secretion and suppress glucagon release in response to meals. This dual action helps improve blood glucose control in patients with type 2 diabetes. Vildagliptin is often used in combination with other antidiabetic medications and offers a well-tolerated option with a low risk of hypoglycemia.

Overview of Clinical Research

Novartis has since withdrawn its intent to submit vildagliptin to the FDA, as of July 2008. It was approved in Feb 2008 by European Medicines Agency for use within the EU and is listed on the Australian PBS with certain restrictions.

Reference

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