For research use only. Not for therapeutic Use.
Vinblastine sulfate（Cat No.:A001147）is a vinca alkaloid chemotherapeutic agent derived from the periwinkle plant (Catharanthus roseus). It works by inhibiting microtubule formation, disrupting mitosis and preventing cancer cell division. Commonly used in the treatment of various malignancies, including Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and testicular cancer, vinblastine is typically administered intravenously. While effective, it can cause side effects such as bone marrow suppression, neuropathy, and gastrointestinal disturbances. Its mechanism of action and clinical utility make vinblastine a crucial component in combination chemotherapy regimens for managing aggressive cancers.
| Catalog Number | A001147 |
| CAS Number | 143-67-9 |
| Synonyms | NSC49842 |
| Molecular Formula | C46H58N4O9S.H2SO4 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | >28.9mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid |
| InChI | InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1 |
| InChIKey | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
| SMILES | CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O |
| Reference | <br /> |
