For research use only. Not for therapeutic Use.
Vincamone（Cat No.:I003721） is a metabolite of vincamine and belongs to the class of vinca alkaloids. It functions as a vasodilator, meaning it relaxes and widens blood vessels, leading to increased blood flow. This property makes vincamone potentially useful in the treatment of various conditions related to poor blood circulation, such as cerebral vascular disorders and peripheral vascular diseases.
| Catalog Number | I003721 |
| CAS Number | 4880-88-0 |
| Molecular Formula | C19H22N2O |
| Purity | ≥95% |
| Target | Drug Metabolite |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one |
| InChI | InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1 |
| InChIKey | WYJAPUKIYAZSEM-MOPGFXCFSA-N |
| SMILES | CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2 |
| Reference | </br>1:Vinburnine decelerates [3H]N-methylscopolamine binding to recombinant human muscarinic M1-M4 acetylcholine receptors. Maksay G, Bíró T, Kiss B.Eur J Pharmacol. 2004 Jan 12;483(2-3):229-32. PMID: 14729111 </br>2:Red blood cell metabolism and hemoglobin oxygen affinity. Effect of vinburnine on normobaric hypoxic rats. Louajri A, Harraga S, Toubin G, Kantelip JP.Biol Pharm Bull. 1999 Aug;22(8):773-4. PMID: 10480311 </br>3:[Lymphocytic colitis likely attributable to use of vinburnine (Cervoxan)]. Chauveau E, Prignet JM, Carloz E, Duval JL, Gilles B.Gastroenterol Clin Biol. 1998 Mar;22(3):362. French. No abstract available. PMID: 9762227 Free Article</br>4:Bullous fixed drug eruption induced by vinburnine. Schena D, Menegazzi S, Barba A.Contact Dermatitis. 1992 Sep;27(3):187. No abstract available. PMID: 1451466 </br>5:[The effects of the acute administration of vinburnine on blood rheology, oxygen transport and regional circulation under normal conditions and in hypoxemia. In vivo research]. Domini L, Acciavatti A, Galigani C, Saletti M, De Franco V, Pecchi S, Auteri A, Di Perri T.Recenti Prog Med. 1990 Nov;81(11):716-23. Italian. PMID: 2287808 </br>6:[The effects of vinburnine on the blood rheology parameters and on the oxyhemoglobin dissociation curve and 2,3-diphosphoglycerate. In vitro research]. Acciavatti A, Domini L, Galigani C, Saletti M, Guideri F, Auteri A, Di Perri T.Recenti Prog Med. 1990 Nov;81(11):710-5. Italian. PMID: 2287807 </br>7:Effects of vinburnine on experimental models of learning and memory impairments. Drago F, Grassi M, Valerio C, Spadaro F, D/’Agata V, Lauria N.Pharmacol Biochem Behav. 1990 Sep;37(1):53-7. PMID: 2263666 </br>8:[The effect of modification of excipients for the bioavailability of vinburnine]. Sado PA, Gibassier D, Leverge R.J Pharm Belg. 1989 May-Jun;44(3):221-9. French. PMID: 2795425 </br>9:Comparative evaluation of scavenger properties of exifone, piracetam and vinburnine. Bentue-Ferrer D, Philouze V, Pape D, Reymann JM, Allain H, Van den Driessche J.Fundam Clin Pharmacol. 1989;3(4):323-8. PMID: 2807130 </br>10:[The oral liquid form of vinburnine: biopharmaceutics]. Sado PA, Gibassier D, Leverge R.J Pharm Belg. 1989 Jan-Feb;44(1):50-9. French. PMID: 2724048 |
