Vinorelbine

• CAT Number: I004666
• CAS Number: 71486-22-1
• Molecular Formula: C45H54N4O8
• Molecular Weight: 778.93
• Purity: ≥95%
• Target: Anti-mitotic
• Solubility: DMSO ≥154mg/mL Water <1.2mg/mL Ethanol ≥154mg/mL
• Storage: Store at -20C

Vinorelbine (Cat.No:I004666) is a potent chemotherapy drug used in the treatment of various cancers, particularly lung cancer and breast cancer. As a vinca alkaloid, it works by disrupting microtubule formation, inhibiting cell division, and ultimately suppressing tumor growth. Its efficacy and manageable side effects make it a valuable option in oncology.

Reference

[1]. Liem AA et al. Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines. Br J Cancer. 2003 Apr 22;88(8):1281-4

[2]. Awada A, Dirix L, Manso Sanchez L, Xu B, Luu T, Diéras V, Hershman DL, Agrapart V, Ananthakrishnan R, Staroslawska E.Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2-positive metastatic breast cancer pretreated with anti-HER2 therapy.Ann Oncol. 2012 Sep 11.

[3]. Zimling ZG, S?rensen JB, Gerds TA, Bech C, Andersen CB, Santoni-Rugiu E.A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesothelioma.Cancer Chemother Pharmacol. 2012 Sep 8.

[4]. Fang D, Sun L, Lin S, Zhou L, Su N, Yuan S, Yu B.Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion.Exp Biol Med (Maywood). 2012 Sep 3.

[5]. Addeo R, Sperlongano P, Montella L, Vincenzi B, Carraturo M, Iodice P, Russo P, Parlato C, Salzano A, Cennamo G, Lombardi A, Sperlongano R, Prete SD, Caraglia M.Protracted low dose of oral vinorelbine and temozolomide with whole-brain radiotherapy in the treatment for breast cancer patients with brain metastases.Cancer Chemother Pharmacol. 2012 Aug 14.