For research use only. Not for therapeutic Use.
Virstatin inhibits the pili system synthesis and prevents A. baumannii biofilm formation. Virstatin also inhibits dimerization of the transcriptional activator ToxT[1][2].
| Catalog Number | R066916 |
| CAS Number | 88909-96-0 |
| Synonyms | 4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butanoic acid |
| Molecular Formula | C16H13NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H13NO4/c18-13(19)8-3-9-17-15(20)11-6-1-4-10-5-2-7-12(14(10)11)16(17)21/h1-2,4-7H,3,8-9H2,(H,18,19) |
| InChIKey | ZHXRDXTYPCPBTI-UHFFFAOYSA-N |
| SMILES | C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCC(=O)O |
| Reference | [1]. Nait Chabane Y, et al. Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii. BMC Microbiol. 2014 Mar 12;14:62. [2]. Shakhnovich EA, et al. Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2372-7. |
