Visomitin

• CAT Number: R030657
• CAS Number: 934826-68-3
• Molecular Formula: C36H42O2P • Br
• Molecular Weight: 617.6
• Purity: ≥95%
• Synonyms: [10-(4,5-Dimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium Bromide; SKQ1
• Target: NF-κB
• Storage: -20°C
• InChIKey: WYHFWTRUGAFNKW-UHFFFAOYSA-M

SKQ1 (bromide) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS). SKQ1 prevents neuronal loss and synaptic damage in a rat model of spontaneous Alzheimer’s disease, as well as decreases severity of arthritic lesions in rats. SKQ1 slows development of age-related ocular pathologies in murine, porcine, bovine, and canine model systems. It also prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction.

Reference

1: Samuilov VD, Kiselevsky DB. Effect of Cationic Plastoquinone SkQ1 on Electron Transfer Reactions in Chloroplasts and Mitochondria from Pea Seedlings. Biochemistry (Mosc). 2015 Apr;80(4):417-23. doi: 10.1134/S0006297915040045. PubMed PMID: 25869358.
2: Iomdina EN, Khoroshilova-Maslova IP, Robustova OV, Averina OA, Kovaleva NA, Aliev G, Reddy VP, Zamyatnin AA Jr, Skulachev MV, Senin II, Skulachev VP. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. Front Biosci (Landmark Ed). 2015 Jan 1;20:892-901. PubMed PMID: 25553485.
3: Manskikh VN, Krasilshchikova MS, Vygodin VA, Egorov MV. Effect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice. Biochemistry (Mosc). 2014 Oct;79(10):1136-9. doi: 10.1134/S0006297914100162. PubMed PMID: 25519073.