Vitamin D3

For research use only. Not for therapeutic Use.

  • CAT Number: A000701
  • CAS Number: 67-97-0
  • Molecular Formula: C27H44O
  • Molecular Weight: 384.6
  • Purity: ≥95%
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Vitamin D3(CAT: A000701) is a vital compound in the realm of pharmaceuticals and human nutrition. It is one of the two main forms of vitamin D that humans require for their well-being. Vitamin D3 plays a crucial role in calcium absorption and bone health, making it essential for the prevention of conditions like osteoporosis and rickets. Additionally, it has been studied for its potential benefits in immune system support and in reducing the risk of certain diseases.


Catalog Number A000701
CAS Number 67-97-0
Synonyms

Cholecalciferol; Calciol; Colecalciferol; 67-97-0; VITAMIN D

Molecular Formula C27H44O
Purity ≥95%
Target Metabolic Enzyme/Protease
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChIKey QYSXJUFSXHHAJI-YRZJJWOYSA-N
SMILES CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Reference

1: Kanhere M, He J, Chassaing B, Ziegler TR, Alvarez JA, Ivie EA, Hao L, Hanfelt
J, Gewirtz AT, Tangpricha V. Bolus weekly vitamin D3 supplementation impacts gut
and airway microbiota in adults with cystic fibrosis: a double-blind, randomized,
placebo-controlled clinical trial. J Clin Endocrinol Metab. 2017 Nov 16. doi:
10.1210/jc.2017-01983. [Epub ahead of print] PubMed PMID: 29161417.
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2: Zhang JH, Chen YP, Yang X, Li CQ. Vitamin D3 levels and NLRP3 expression in
murine models of obese asthma: association with asthma outcomes. Braz J Med Biol
Res. 2017 Nov 13;51(1):e6841. doi: 10.1590/1414-431X20176841. PubMed PMID:
29160418.

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3: Scricciolo A, Roncoroni L, Lombardo V, Ferretti F, Doneda L, Elli L. Vitamin
D3 Versus Gliadin: A Battle to the Last Tight Junction. Dig Dis Sci. 2017 Nov 20.
doi: 10.1007/s10620-017-4848-8. [Epub ahead of print] PubMed PMID: 29159680.
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4: Rolf L, Muris AH, Theunissen R, Hupperts R, Damoiseaux J, Smolders J. Vitamin
D(3) supplementation and the IL-2/IL-2R pathway in multiple sclerosis:
Attenuation of progressive disturbances? J Neuroimmunol. 2017 Nov 10. pii:
S0165-5728(17)30208-4. doi: 10.1016/j.jneuroim.2017.11.007. [Epub ahead of print]
PubMed PMID: 29153546.
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5: Young LR, Backus RC. Serum 25-hydroxyvitamin D(3) and 24R,25-dihydroxyvitamin
D(3) concentrations in adult dogs are more substantially increased by oral
supplementation of 25-hydroxyvitamin D(3) than by vitamin D(3). J Nutr Sci. 2017
Jun 20;6:e30. doi: 10.1017/jns.2017.8. eCollection 2017. PubMed PMID: 29152235;
PubMed Central PMCID: PMC5672302.

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6: Kroschwald L, Suttorp M, Tauer JT, Zimmermann N, Günther C, Bauer A.
Off&#8209;target effect of imatinib and nilotinib on human vitamin D3 metabolism. Mol
Med Rep. 2017 Nov 3. doi: 10.3892/mmr.2017.7952. [Epub ahead of print] PubMed
PMID: 29115640.

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7: Gou SH, Liu BJ, Han XF, Wang L, Zhong C, Liang S, Liu H, Qiang Y, Zhang Y, Ni
JM. Anti-atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum
mixture in high-fat emulsion- and vitamin D(3)-induced atherosclerotic rats. J
Chin Med Assoc. 2017 Oct 26. pii: S1726-4901(17)30271-X. doi:
10.1016/j.jcma.2017.08.018. [Epub ahead of print] PubMed PMID: 29107606.
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8: Yalamanchili V, Gallagher JC. Dose ranging effects of vitamin D3 on the
geriatric depression score: A clinical trial. J Steroid Biochem Mol Biol. 2017
Nov 2. pii: S0960-0760(17)30325-4. doi: 10.1016/j.jsbmb.2017.10.025. [Epub ahead
of print] PubMed PMID: 29104103.
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9: Morgese F, Soldato D, Pagliaretta S, Giampieri R, Brancorsini D, Torniai M,
Rinaldi S, Savini A, Onofri A, Scarpelli M, Berardi R. Impact of
phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide
polymorphisms on the outcome of malignant melanoma patients. Oncotarget. 2017 May
30;8(44):75914-75923. doi: 10.18632/oncotarget.18304. eCollection 2017 Sep 29.
PubMed PMID: 29100280; PubMed Central PMCID: PMC5652674.
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10: Moretti HD, Colucci VJ, Berry BD. Vitamin D(3) repletion versus placebo as
adjunctive treatment of heart failure patient quality of life and hormonal
indices: a randomized, double-blind, placebo-controlled trial. BMC Cardiovasc
Disord. 2017 Oct 30;17(1):274. doi: 10.1186/s12872-017-0707-y. PubMed PMID:
29084522; PubMed Central PMCID: PMC5663043.

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