VN339

For research use only. Not for therapeutic Use.

  • CAT Number: I038090
  • Molecular Formula: C22H16N4O
  • Molecular Weight: 352.40
  • Purity: 98%
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VN339(CAT: I038090) is a selective and potent agonist of the thyroid hormone receptor β (THRβ), extensively studied in metabolic and cardiovascular research. By targeting THRβ, VN339 demonstrates potential in modulating lipid metabolism, promoting cholesterol reduction, and improving metabolic homeostasis. This compound is widely used to explore therapeutic strategies for conditions such as hypercholesterolemia, nonalcoholic fatty liver disease (NAFLD), and obesity. Its receptor specificity minimizes off-target effects, offering a safer profile for preclinical investigations. VN339 provides researchers with a reliable tool to dissect THRβ-related pathways and advance the development of novel treatments for metabolic disorders.


Catalog Number I038090
Synonyms

VN339; VN-339; VN 339

Molecular Formula C22H16N4O
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1-Methyl-4-(9-(3-(pyridin-4-yl)-phenyl)-7-oxa-2-aza-bicyclo[4.3.0]nona-1,3,5,8-tetraen-3-yl)-1H-pyrazole
InChI InChI=1S/C22H16N4O/c1-26-13-18(12-24-26)20-5-6-21-22(25-20)19(14-27-21)17-4-2-3-16(11-17)15-7-9-23-10-8-15/h2-14H,1H3
InChIKey HEAGNKNMQVIVMM-UHFFFAOYSA-N
SMILES CN1N=CC(C2=CC=C3OC=C(C4=CC=CC(C5=CC=NC=C5)=C4)C3=N2)=C1

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