Vofopitant dihydrochloride

• CAT Number: M037714
• CAS Number: 168266-51-1
• Molecular Formula: C21H25Cl2F3N6O
• Molecular Weight: 505.37
• Purity: ≥95%
• Target: Neuronal Signaling
• Storage: Desiccate at -20C
• IUPAC Name: (2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine;dihydrochloride
• InChI: InChI=1S/C21H23F3N6O.2ClH/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14;;/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3;2*1H/t17-,19-;;/m0../s1
• InChIKey: YVNRXILPJNISEM-FFUVTKDNSA-N
• SMILES: COC1=C(C=C(C=C1)N2C(=NN=N2)C(F)(F)F)CNC3CCCNC3C4=CC=CC=C4.Cl.Cl

Vofopitant dihydrochloride（Cat No.:M037714） is a potent neurokinin-1 (NK1) receptor antagonist formulated as a dihydrochloride salt to enhance its solubility and stability. This drug is primarily explored for its potential in managing chemotherapy-induced nausea and vomiting (CINV), a common and debilitating side effect of cancer treatment. By blocking the NK1 receptor, the volitant effectively inhibits the action of substance P, a neuropeptide involved in the vomiting reflex. This mechanism makes it a valuable candidate for inclusion in antiemetic therapy regimens, aiming to improve the quality of life for patients undergoing chemotherapy.