Vofopitant

• CAT Number: I010039
• CAS Number: 168266-90-8
• Molecular Formula: C21H23F3N6O
• Molecular Weight: 432.45
• Purity: ≥95%
• Synonyms: GR-205,171; GR205,171; GR 205,171; GR-205171; GR205171; GR 205171;Vofopitant.;(2S,3S)-N-[(2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl)methyl]-2-phenylpiperidin-3-amine
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine
• InChI: InChI=1S/C21H23F3N6O/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3/t17-,19-/m0/s1
• InChIKey: XILNRORTJVDYRH-HKUYNNGSSA-N
• SMILES: COC1=C(C=C(C=C1)N2C(=NN=N2)C(F)(F)F)CNC3CCCNC3C4=CC=CC=C4

Vofopitant(CAT: I010039) is a potent and selective antagonist of the neurokinin 1 (NK1) receptor, which is involved in modulating stress, anxiety, and pain responses by binding to the neuropeptide substance P. It has been studied for its potential therapeutic applications in conditions such as depression, anxiety disorders, chemotherapy-induced nausea and vomiting (CINV), and pain management. Vofopitant is particularly valuable in neuroscience and pharmacology research, aiding in the exploration of NK1 receptor-mediated pathways and the development of targeted therapies. Its high specificity and efficacy make Vofopitant a crucial tool for advancing research into neurokinin receptor function and therapeutic applications.