Volanesorsen

• CAT Number: I043998
• CAS Number: 915430-78-3
• Molecular Weight: 7165.00
• Purity: ≥95%

Volanesorsen is an antisense oligonucleotide thay targes Apolipoprotein C-III (APOC3)
mRNA. Volanesorsen is used for the study of familial chylomicronemia syndrome.

Reference

[1]. Graham MJ, Lee RG, Bell TA 3rd, et al. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Circ Res. 2013;112(11):1479-1490.
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[2]. Gaudet D, Brisson D, Tremblay K, et al. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014;371(23):2200-2206.
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[3]. Post N, Yu R, Greenlee S, et al. Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019;47(10):1164-1173.
 [Content Brief]