VP-4604

• CAT Number: I043594
• CAS Number: 64268-93-5
• Molecular Formula: C11H14N2O4S
• Molecular Weight: 270.30
• Purity: ≥95%
• Synonyms: 1-(4-nitrophenyl)sulfonylpiperidine
• InChI: InChI=1S/C11H14N2O4S/c14-13(15)10-4-6-11(7-5-10)18(16,17)12-8-2-1-3-9-12/h4-7H,1-3,8-9H2
• InChIKey: XDPAFNJUKBYWBZ-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)[N+](=O)[O-]

VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%[1].
VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%[1].
VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells) [1].
VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively[1].

Reference

[1]. Vitalii Palchykov, et al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research. 2022. 31: 284-292.