For research use only. Not for therapeutic Use.
VPC-13566, a BF3-specific small molecule, is an androgen receptor (AR) inhibitor. VPC-13566 is effective in inhibiting AR transcriptional activity in vitro as well as the growth of AR-dependent PCa cell lines. VPC-13566 can be used as a chemical probe to help identify unknown AR partners.VPC-13566 can be used for the research of cancer.
| Catalog Number | I012024 |
| CAS Number | 218464-59-6 |
| Synonyms | 2-(7-methyl-1H-indol-3-yl)quinoline |
| Molecular Formula | C18H14N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H14N2/c1-12-5-4-7-14-15(11-19-18(12)14)17-10-9-13-6-2-3-8-16(13)20-17/h2-11,19H,1H3 |
| InChIKey | FPKBNOVQNMJTEJ-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=CC=C1)C(=CN2)C3=NC4=CC=CC=C4C=C3 |
| Reference | [1]. Lallous N, et al. Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation. Mol Cancer Ther. 2016 Dec;15(12):2936-2945. |
