For research use only. Not for therapeutic Use.
VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].
| Catalog Number | I010015 |
| CAS Number | 449173-19-7 |
| Synonyms | [(2R)-2-amino-3-(3-octylanilino)-3-oxopropyl] dihydrogen phosphate |
| Molecular Formula | C17H29N2O5P |
| Purity | ≥95% |
| InChI | InChI=1S/C17H29N2O5P/c1-2-3-4-5-6-7-9-14-10-8-11-15(12-14)19-17(20)16(18)13-24-25(21,22)23/h8,10-12,16H,2-7,9,13,18H2,1H3,(H,19,20)(H2,21,22,23)/t16-/m1/s1 |
| InChIKey | MRUSUGVVWGNKFE-MRXNPFEDSA-N |
| SMILES | CCCCCCCCC1=CC(=CC=C1)NC(=O)C(COP(=O)(O)O)N |
| Reference | [1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8. |
