VPC-80051 racemate

• CAT Number: I038114
• CAS Number: 877969-69-2
• Molecular Formula: C16H13F2N3O
• Molecular Weight: 301.29
• Purity: ≥95%
• Synonyms: N-[1-(3,4-difluorophenyl)ethyl]-1H-indazole-3-carboxamide
• InChI: InChI=1S/C16H13F2N3O/c1-9(10-6-7-12(17)13(18)8-10)19-16(22)15-11-4-2-3-5-14(11)20-21-15/h2-9H,1H3,(H,19,22)(H,20,21)
• InChIKey: MVHNHGGJTMFAQP-UHFFFAOYSA-N
• SMILES: CC(C1=CC(=C(C=C1)F)F)NC(=O)C2=NNC3=CC=CC=C32

VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor[1].
VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. hnRNP A1 is a multifunctional RNA-binding protein that regulates alternative pre-mRNA splicing, transcription, nucleocytoplasmic shuttling, miRNA processing, and telomere elongation maintenance, as well as translation of cellular transcripts both in physiological and pathological conditions[1].

Reference

[1]. Carabet LA, et al. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019;24(4):763. Published 2019 Feb 20.
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