For research use only. Not for therapeutic Use.
VPC171(CAT: I038105) is a compound known as a positive allosteric modulator (PAM) of the adenosine A1 receptor (A1R). PAMs of the A1R are being studied for their potential as a novel treatment approach for neuropathic pain. By modulating the activity of the A1R, VPC171 enhances the receptor’s response to endogenous adenosine, leading to the inhibition of pain signals and potential analgesic effects. This mechanism of action suggests that VPC171 may have therapeutic applications in the management of neuropathic pain.
| Catalog Number | I038105 |
| CAS Number | 1018830-99-3 |
| Synonyms | VPC171; VPC 171; VPC-171; |
| Molecular Formula | C18H12F3NOS |
| Purity | 98% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | [2-amino-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl]-phenylmethanone |
| InChI | InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2 |
| InChIKey | HNHLVOBHWXLIGP-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(N)SC=C1C2=CC=CC(C(F)(F)F)=C2)C3=CC=CC=C3 |
| Reference | 1. Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. (2009) Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J. Med. Chem., 52 (14): 4543-7. [PMID:19514747] |
