Vps34-IN-2

• CAT Number: I013057
• CAS Number: 1523404-29-6
• Molecular Formula: C₁₈H₂₅F₃N₄O₃
• Molecular Weight: 402.41
• Purity: ≥95%
• Target: Anti-infection
• Solubility: DMSO
• Storage: Sealed in dry,Room Temperature
• IUPAC Name: (8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one
• InChI: InChI=1S/C18H25F3N4O3/c1-11(2)13(26)9-25-14(18(19,20)21)4-5-24-16(27)8-15(22-17(24)25)23-6-7-28-10-12(23)3/h8,11-12,14H,4-7,9-10H2,1-3H3/t12-,14+/m1/s1
• InChIKey: ITCIAOUZMPREOO-OCCSQVGLSA-N
• SMILES: C[C@@H]1COCCN1C2=CC(=O)N3CC[C@H](N(C3=N2)CC(=O)C(C)C)C(F)(F)F

Vps34-IN-2（Cat No.:I013057）is a potent and selective inhibitor of Vps34, a class III phosphatidylinositol 3-kinase (PI3K) involved in autophagy and vesicular trafficking. By inhibiting Vps34 activity, Vps34-IN-2 disrupts autophagosome formation, making it a valuable tool for studying the autophagy pathway and related cellular processes. This compound is useful for investigating Vps34’s role in cancer, neurodegenerative diseases, and other conditions where autophagy is implicated. Vps34-IN-2 is essential for researchers aiming to elucidate the complexities of autophagy and develop potential therapeutic approaches.

Reference

[1]. Pasquier B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015 Jan 8;58(1):376-400.