For research use only. Not for therapeutic Use.
VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].
VRT-532 (15 µM) directly binds reconstituted G551D-CFTR and modifies its ATPase activity[1].
| Catalog Number | I014757 |
| CAS Number | 38214-71-0 |
| Synonyms | 4-methyl-2-(3-phenyl-1H-pyrazol-5-yl)phenol |
| Molecular Formula | C16H14N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14N2O/c1-11-7-8-16(19)13(9-11)15-10-14(17-18-15)12-5-3-2-4-6-12/h2-10,19H,1H3,(H,17,18) |
| InChIKey | AQWKVJFRGORALM-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)O)C2=CC(=NN2)C3=CC=CC=C3 |
| Reference | [1]. Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. [2]. Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. |
