For research use only. Not for therapeutic Use.
VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
| Catalog Number | I038126 |
| CAS Number | 65194-64-1 |
| Synonyms | VT101; VT-101; VT 101; |
| Molecular Formula | C14H20N2O4S |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | methyl 2-(cyclohexylamino)-5-sulfamoylbenzoate |
| InChI | InChI=1S/C14H20N2O4S/c1-20-14(17)12-9-11(21(15,18)19)7-8-13(12)16-10-5-3-2-4-6-10/h7-10,16H,2-6H2,1H3,(H2,15,18,19) |
| InChIKey | CCFPLJFSHRAQPV-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(C=CC(S(=O)(N)=O)=C1)NC2CCCCC2)OC |
| Reference | Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Epub ahead of print. PMID: 33850002. |
