For research use only. Not for therapeutic Use.
Potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist or negative allosteric modulator (NAM) (IC50: 61 nM)
| Catalog Number | R032706 |
| CAS Number | 1274859-33-4 |
| Molecular Formula | C15H9FN2S |
| Purity | ≥95% |
| IUPAC Name | 3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile |
| InChI | InChI=1S/C15H9FN2S/c1-9-18-14-7-11(2-3-15(14)19-9)12-4-10(8-17)5-13(16)6-12/h2-7H,1H3 |
| SMILES | CC1=NC2=C(S1)C=CC(=C2)C3=CC(=CC(=C3)C#N)F |
| Reference | CW Lindsley et al. (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem. Neurosci. 2011, 2(8), 471-482. |
