For research use only. Not for therapeutic Use.
VU 0364739 hydrochloride (Cat.No:I010903) is a potent and selective phospholipase D2 (PLD2) inhibitor (IC<sub>50</sub> = 20 nM); displays 75-fold selectivity against PLD1 (IC<sub>50</sub> = 1500 nM).
| Catalog Number | I010903 |
| CAS Number | 1244640-48-9 |
| Synonyms | N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide |
| Molecular Formula | C26H28ClFN4O2 |
| Purity | ≥95% |
| Target | Phospholipase |
| Solubility | Soluble to 100 mM in DMSO |
| Storage | Desiccate at RT |
| IUPAC Name | N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide;hydrochloride |
| InChI | InChI=1S/C26H27FN4O2.ClH/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21;/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33);1H |
| InChIKey | RYLAMDMOILNBKN-UHFFFAOYSA-N |
| SMILES | C1CN(CCC12C(=O)NCN2C3=CC(=CC=C3)F)CCNC(=O)C4=CC5=CC=CC=C5C=C4.Cl |
