VU 0463271

• CAT Number: I011011
• CAS Number: 1391737-01-1
• Molecular Formula: C19H18N4OS2
• Molecular Weight: 382.5
• Purity: ≥95%
• Synonyms: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
• Target: Potassium Channel
• Solubility: Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
• Storage: Store at +4C
• IUPAC Name: N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
• InChI: InChI=1S/C19H18N4OS2/c1-13-11-26-19(20-13)23(15-7-8-15)18(24)12-25-17-10-9-16(21-22-17)14-5-3-2-4-6-14/h2-6,9-11,15H,7-8,12H2,1H3
• InChIKey: DPONSKCACOZTGN-UHFFFAOYSA-N
• SMILES: CC1=CSC(=N1)N(C2CC2)C(=O)CSC3=NN=C(C=C3)C4=CC=CC=C4

VU 0463271 (Cat.No:I011011) is a potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters.