For research use only. Not for therapeutic Use.
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM[1].
VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels[2].
| Catalog Number | I010742 |
| CAS Number | 890764-63-3 |
| Synonyms | N-[2-(2-fluorophenyl)-5-phenylpyrazol-3-yl]-4-nitrobenzamide |
| Molecular Formula | C22H15FN4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H15FN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28) |
| InChIKey | BRAZLURTFMCAHU-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4F |
| Reference | [1]. Tomas de Paulis, et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem. 2006 Jun 1;49(11):3332-44. [2]. J G Doria, et al. Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington’s disease. Br J Pharmacol. 2013 Jun;169(4):909-21. |
