For research use only. Not for therapeutic Use.
VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (K<sub>ir</sub>) 6.2 and sulfonylurea receptor (SUR) 1 (EC<sub>50</sub> = 7 µM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing K<sub>ir</sub>6.1 or K<sub>ir</sub>6.2 channels over SUR2A, K<sub>ir</sub>2.1, K<sub>ir</sub>2.2, K<sub>ir</sub>2.3, K<sub>ir</sub>3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.
| Catalog Number | R067052 |
| CAS Number | 333415-38-6 |
| Synonyms | 7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Molecular Formula | C18H22N4O2 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Storage | -20°C |
| IUPAC Name | 7-[(4-tert-butylphenyl)methyl]-1,3-dimethylpurine-2,6-dione |
| InChI | InChI=1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3 |
| InChIKey | ZFZAIHKQJBMYLO-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)CN2C=NC3=C2C(=O)N(C(=O)N3C)C |
| Reference | 1.Raphemot, R.,Swale, D.R.,Dadi, P.K., et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol. Pharmacol. 85(6), 858-865 (2014). |
