For research use only, not for therapeutic use.
VU0119498 (CAT: I038139) is a compound that acts as an agonist of the M1 muscarinic receptor and a positive allosteric modulator (PAM) of pan mAChR M3 and M5 receptors. It exhibits an EC50 value of 3.1 μM for M1 receptor activation. By targeting these receptors, VU0119498 can modulate cholinergic neurotransmission in the central nervous system. Additionally, VU0119498 has shown potential as a neuroprotective agent, suggesting its ability to protect neuronal cells from damage or degeneration.
Catalog Number | I038139 |
CAS Number | 79183-37-2 |
Synonyms | VU0119498, VU 0119498, VU-0119498 |
Molecular Formula | C15H10BrNO2 |
Purity | 98% |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
IUPAC Name | 1-[(4-bromophenyl)methyl]indole-2,3-dione |
InChI | InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2 |
InChIKey | DELLOEULSHGYCG-UHFFFAOYSA-N |
SMILES | O=C1N(CC2=CC=C(Br)C=C2)C3=C(C=CC=C3)C1=O |
Reference | 1: Bridges TM, Kennedy JP, Hopkins CR, Conn PJ, Lindsley CW. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22. doi: 10.1016/j.bmcl.2010.08.042. Epub 2010 Aug 12. PubMed PMID: 20801651; PubMed Central PMCID: PMC3179183. |