For research use only. Not for therapeutic Use.
VU0134992 hydrochloride(CAT:I016422) is a selective small-molecule inhibitor of Kir4.1 potassium channels (KCNJ10), widely used as a research tool in neuroscience and renal physiology. Kir4.1 channels are critical for maintaining potassium homeostasis, glial cell function, and neuronal excitability. By selectively blocking Kir4.1, VU0134992 hydrochloride enables mechanistic studies of astrocytic regulation, synaptic transmission, and ion transport in the central nervous system. It is also valuable for exploring the role of Kir4.1 in kidney physiology and associated pathologies. This compound provides a precise pharmacological approach to dissect Kir4.1 channel function and supports drug discovery in neurological and metabolic disorders.
| CAS Number | 1052515-91-9 |
| Synonyms | 2-(2-bromo-4-propan-2-ylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide;hydrochloride |
| Molecular Formula | C20H32BrClN2O2 |
| Purity | ≥95% |
| IUPAC Name | 2-(2-bromo-4-propan-2-ylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide;hydrochloride |
| InChI | InChI=1S/C20H31BrN2O2.ClH/c1-13(2)14-7-8-17(16(21)9-14)25-12-18(24)22-15-10-19(3,4)23-20(5,6)11-15;/h7-9,13,15,23H,10-12H2,1-6H3,(H,22,24);1H |
| InChIKey | QXKQUPCNSXWIDX-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC(=C(C=C1)OCC(=O)NC2CC(NC(C2)(C)C)(C)C)Br.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
