VU0152099

• CAT Number: I038140
• CAS Number: 612514-42-8
• Molecular Formula: C18H17N3O3S
• Molecular Weight: 355.41
• Purity: 98%
• Synonyms: VU0152099, VU 0152099, VU-0152099
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide
• InChI: InChI=1S/C18H17N3O3S/c1-9-5-10(2)21-18-14(9)15(19)16(25-18)17(22)20-7-11-3-4-12-13(6-11)24-8-23-12/h3-6H,7-8,19H2,1-2H3,(H,20,22)
• InChIKey: AZOGCTMOKNTHIU-UHFFFAOYSA-N
• SMILES: O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCC3=CC=C(OCO4)C4=C3

VU0152100（Cat No.:I038140） is a potent and selective allosteric potentiator of the M4 subtype of muscarinic acetylcholine receptors (mAChR). It exhibits a significant enhancing effect on the activity of M4 mAChR. The EC50 value, a measure of potency, is determined to be 380 ± 93 nM, indicating its effectiveness in modulating the activity of M4 mAChR. The selectivity and potency of VU0152100 make it a valuable tool for studying the function and therapeutic potential of M4 mAChR in various biological processes and disease states.

Reference

1. Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.