VU0152100

• CAT Number: I003489
• CAS Number: 409351-28-6
• Molecular Formula: C18H19N3O2S
• Molecular Weight: 341.43
• Purity: ≥95%
• Synonyms: 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
• Target: Neuronal Signaling
• Solubility: DMSO >50 mg/mL
• Storage: Store at -20C
• IC50: 380 ± 93 nM (EC50) [1]
• InChI: MDNWGCQSCGNTKH-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC=C(C=C3)OC)N)C

VU0152100(CAT: I003489) is a potent and selective allosteric potentiator of the M4 muscarinic acetylcholine receptor (mAChR). By enhancing receptor signaling through an allosteric binding site, it amplifies cholinergic activity without directly activating the receptor, offering precision in modulating M4 mAChR-associated pathways. This compound is particularly valuable in neuroscience research, supporting studies on disorders such as schizophrenia and Parkinson’s disease, where M4 receptor modulation plays a critical role. VU0152100 is a vital tool for advancing research into the therapeutic potential of M4 mAChR potentiators and their role in addressing central nervous system disorders.