VU0364289

• CAT Number: I012127
• CAS Number: 1242443-29-3
• Molecular Formula: C20H21N3O2
• Molecular Weight: 335.407
• Purity: ≥95%
• Synonyms: 2-(4-(2-(Benzyloxy)acetyl)piperazin-1-yl)benzonitrile
• Target: Neuronal Signaling
• IUPAC Name: 2-[4-(2-phenylmethoxyacetyl)piperazin-1-yl]benzonitrile
• InChI: InChI=1S/C20H21N3O2/c21-14-18-8-4-5-9-19(18)22-10-12-23(13-11-22)20(24)16-25-15-17-6-2-1-3-7-17/h1-9H,10-13,15-16H2
• InChIKey: LTPGKAICNBCBPT-UHFFFAOYSA-N
• SMILES: C1CN(CCN1C2=CC=CC=C2C#N)C(=O)COCC3=CC=CC=C3

VU0364289 (CAT: I012127) is a potent and specific Positive Allosteric Modulator (PAM) designed to target the rat metabotropic glutamate receptor 5 (mGluR5). This compound exhibits a remarkable affinity and selectivity for the mGluR5 receptor, a member of the G-protein coupled receptor family involved in neurotransmission and synaptic plasticity. By functioning as a PAM, VU0364289 enhances the receptor’s activity by binding to an allosteric site, ultimately amplifying its response to glutamate neurotransmitters.