VU0364739

• CAT Number: I040935
• CAS Number: 1244639-78-8
• Molecular Formula: C26H27FN4O2
• Molecular Weight: 446.52
• Purity: ≥95%
• Synonyms: N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
• InChI: InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
• InChIKey: MSTXJJGAXXJCBY-UHFFFAOYSA-N
• SMILES: C1CN(CCC12C(=O)NCN2C3=CC(=CC=C3)F)CCNC(=O)C4=CC5=CC=CC=C5C=C4

VU0364739 (Cat No.: I040935) is a selective positive allosteric modulator (PAM) of the muscarinic acetylcholine receptor M₁ (M₁ mAChR), used in neurological and psychiatric research. It enhances M₁ receptor signaling without directly activating the receptor, supporting studies on cognitive function, memory, and synaptic plasticity. VU0364739 is especially relevant for exploring therapeutic strategies in Alzheimer’s disease, schizophrenia, and other cognitive disorders. Its receptor subtype selectivity enables precise modulation of cholinergic pathways. For research use only in laboratory and preclinical investigations.

Reference

[1]. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.
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