For research use only. Not for therapeutic Use.
VU0418506(CAT: I038152) is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). It has been developed as a research tool to study the function of mGlu4 receptors in various biological processes. By binding to the receptor at an allosteric site, VU0418506 enhances the activity of mGlu4, which can have downstream effects on neurotransmission and neuronal signaling. The selective modulation of mGlu4 with VU0418506 has potential applications in understanding the role of this receptor in neurological disorders and in the development of therapeutic interventions.
| Catalog Number | I038152 |
| CAS Number | 1330624-42-4 |
| Synonyms | VU0418506; VU-0418506; VU 0418506; |
| Molecular Formula | C12H8ClFN4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine |
| InChI | InChI=1S/C12H8ClFN4/c13-8-6-7(3-4-9(8)14)16-12-11-10(17-18-12)2-1-5-15-11/h1-6H,(H2,16,17,18) |
| InChIKey | SBDWTBISUBYOMI-UHFFFAOYSA-N |
| SMILES | FC1=CC=C(NC2=NNC3=CC=CN=C32)C=C1Cl |
| Reference | 1: Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. doi: 10.1021/acschemneuro.6b00036. Epub 2016 Aug 5. PubMed PMID: 27441572; PubMed Central PMCID: PMC5073817. |
