For research use only. Not for therapeutic Use.
VU0453379（Cat No.:I019054） is a potent and selective positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It can penetrate the central nervous system (CNS), making it suitable for targeting GLP-1R in the brain. With an EC50 (half-maximal effective concentration) of 1.3 μM, VU0453379 demonstrates high affinity and efficacy in modulating GLP-1R activity. GLP-1R is involved in regulating glucose metabolism and appetite, making it a target of interest for the development of therapeutics for metabolic disorders, including type 2 diabetes and obesity.
| Catalog Number | I019054 |
| CAS Number | 1638646-27-1 |
| Molecular Formula | C₂₆H₃₄N₄O₂ |
| Purity | ≥95% |
| Target | GCGR |
| Storage | Store at -20°C |
| IUPAC Name | 2-cyclopentyl-9-methyl-1-oxo-N-[[(2S)-1-propan-2-ylpyrrolidin-2-yl]methyl]pyrido[3,4-b]indole-4-carboxamide |
| InChI | InChI=1S/C26H34N4O2/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1 |
| InChIKey | OEYYOVRNPJSWTO-IBGZPJMESA-N |
| SMILES | CC(C)N1CCCC1CNC(=O)C2=CN(C(=O)C3=C2C4=CC=CC=C4N3C)C5CCCC5 |
| Reference | [1]. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. |
