For research use only. Not for therapeutic Use.
VU0468554 is a selective GIRK inhibitor with IC50 values of 0.85 μM and 2.6 μM for GIRK1/GIRK4 and GIRK1/GIRK2 channels, respectively. VU0468554 more effectively inhibits the cardiac GIRK channel than the neuronal GIRK channel.
KEYWORDS: VU0468554 | Supplier | GIRK inhibitor | VU 0468554 | VU-0468554 | CAS [1448705-21-2] | Potassium | GIRK | Inhibitor | Ion Channels | Cardiac arrhythmia | Cardiac G protein-gated inwardly rectifying K+ channel
| Catalog Number | I047680 |
| CAS Number | 1448705-21-2 |
| Molecular Formula | C20H22N4O |
| Purity | ≥95% |
| IUPAC Name | 1-(3-methylphenyl)-3-(2-phenyl-5-propan-2-ylpyrazol-3-yl)urea |
| InChI | InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-10-5-4-6-11-17)22-20(25)21-16-9-7-8-15(3)12-16/h4-14H,1-3H3,(H2,21,22,25) |
| SMILES | CC1=CC(=CC=C1)NC(=O)NC2=CC(=NN2C3=CC=CC=C3)C(C)C |
| Reference | A Anderson et al. Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying K+ Channels. Mol Pharmacol. 2021 Dec;100(6):540-547. W Wen et al. Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6. |
