For research use only. Not for therapeutic Use.
VU661013 (Cat.No:I019750) is a potent and selective MCL-1 inhibitor. VU661013 exhibits a Ki of 97±30 pM to human MCL-1 in a TR-FRET assay by displacing a fluorescently labeled peptide derived from the pro-apoptotic protein BAK. However, VU661013 does not significantly inhibit BCL-xL (Ki>40 μM) or BCL-2 (Ki=0.73 μM).
| Catalog Number | I019750 |
| CAS Number | 2131184-57-9 |
| Molecular Formula | C₃₉H₃₉Cl₂N₅O₄ |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Reference | [1]. Haley E. Ramsey, et al. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia. Cancer Discov. August 28, 2018. |
