For research use only. Not for therapeutic Use.
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research[1].
NAPE-PLD activator (VU533) (0.1-30 μM, 24 h) has no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells[1].
NAPE-PLD activator (0.1-30 μM, 24 h) increases Nape-pld activity in a concentration-dependent manner in RAW264.7 cells and HepG2 cells[1].
NAPE-PLD activator (10 μM, 6 h) enhances efferocytosis in bone-marrow derived macrophages (BMDM) [1].
| Catalog Number | I040781 |
| CAS Number | 923417-09-8 |
| Synonyms | N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide |
| Molecular Formula | C21H22FN3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22FN3O3S2/c1-13-3-4-14(2)19-18(13)23-21(29-19)24-20(26)15-9-11-25(12-10-15)30(27,28)17-7-5-16(22)6-8-17/h3-8,15H,9-12H2,1-2H3,(H,23,24,26) |
| InChIKey | UKXHDJBIBJBTIU-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=C(C=C1)C)SC(=N2)NC(=O)C3CCN(CC3)S(=O)(=O)C4=CC=C(C=C4)F |
| Reference | [1]. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. |
