For research use only. Not for therapeutic Use.
VU533 (Cat No.: I040781) is a selective inhibitor of the Kir4.1 potassium channel, widely used in neurological disease research. By targeting Kir4.1, which is primarily expressed in astrocytes, VU533 helps elucidate the role of glial potassium buffering in maintaining neuronal excitability and ion homeostasis. It enables the investigation of Kir4.1-related dysfunctions in disorders such as epilepsy, stroke, and multiple sclerosis. VU533 provides a valuable pharmacological tool for exploring glial-neuronal interactions and potential therapeutic avenues targeting astrocytic ion channels. For research use only.
| CAS Number | 923417-09-8 |
| Synonyms | N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide |
| Molecular Formula | C21H22FN3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22FN3O3S2/c1-13-3-4-14(2)19-18(13)23-21(29-19)24-20(26)15-9-11-25(12-10-15)30(27,28)17-7-5-16(22)6-8-17/h3-8,15H,9-12H2,1-2H3,(H,23,24,26) |
| InChIKey | UKXHDJBIBJBTIU-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=C(C=C1)C)SC(=N2)NC(=O)C3CCN(CC3)S(=O)(=O)C4=CC=C(C=C4)F |
| Reference | [1]. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
