For research use only. Not for therapeutic Use.
VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].
VU6010572 (3 mg/kg; i.p.) shows robust efficacy[1].
VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects[2].
| CAS Number | 2126784-39-0 |
| Synonyms | 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]pyridin-2-one |
| Molecular Formula | C20H18FNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1 |
| InChIKey | AUMJXOXUSGIUCB-HNNXBMFYSA-N |
| SMILES | CC(COC1=CC(=O)N(C=C1)C2=CC=C(C=C2)F)OC3=CC=CC=C3 |
| Reference | [1]. Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. [2]. Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST |
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