For research use only. Not for therapeutic Use.
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with K<sub>i</sub> of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.<br>VUF10166 shows low activity to 5-HT<sub>3</sub>AB receptor with K<sub>i</sub> of 22 nM. VUF10166 may be used to can distinguish between 5-HT<sub>3</sub>A and 5-HT<sub>3</sub>AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.
| Catalog Number | R058690 |
| CAS Number | 155584-74-0 |
| Synonyms | 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline; |
| Molecular Formula | C13H15ClN4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| IUPAC Name | 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline |
| InChI | InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3 |
| InChIKey | FFXVTQDGTKEXHF-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl |
