For research use only. Not for therapeutic Use.
VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH₄ receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.
| Catalog Number | I038200 |
| CAS Number | 1605304-31-1 |
| Synonyms | VUF14480; VU-F14480; VUF 14480; |
| Molecular Formula | C17H20N4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-(4-Methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine |
| InChI | InChI=1S/C17H20N4/c1-3-16-18-15(14-7-5-4-6-8-14)13-17(19-16)21-11-9-20(2)10-12-21/h3-8,13H,1,9-12H2,2H3 |
| InChIKey | IQEYEGMWJXOFAC-UHFFFAOYSA-N |
| SMILES | C=CC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1 |
| Reference | 1: Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C, |
