For research use only. Not for therapeutic Use.
VUF14480 (Cat No.: I038200) is a selective agonist of the adenosine A3 receptor, a G-protein coupled receptor involved in regulating inflammation, immune responses, and cell survival. It has potential therapeutic applications in treating conditions such as inflammation, cancer, and cardiovascular diseases. By activating the A3 receptor, VUF14480 modulates immune cell activity and reduces inflammation, making it a candidate for conditions like rheumatoid arthritis and other inflammatory disorders. Ongoing research is exploring its effectiveness and safety in preclinical models and its potential for clinical use in immunomodulatory therapies.
| CAS Number | 1605304-31-1 |
| Synonyms | VUF14480; VU-F14480; VUF 14480; |
| Molecular Formula | C17H20N4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-(4-Methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine |
| InChI | InChI=1S/C17H20N4/c1-3-16-18-15(14-7-5-4-6-8-14)13-17(19-16)21-11-9-20(2)10-12-21/h3-8,13H,1,9-12H2,2H3 |
| InChIKey | IQEYEGMWJXOFAC-UHFFFAOYSA-N |
| SMILES | C=CC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1 |
| Reference | 1: Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C, |
