For research use only. Not for therapeutic Use.
VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI).
| Catalog Number | I047520 |
| CAS Number | 3026500-20-6 |
| Molecular Formula | C20H21F2N3O4S |
| Purity | ≥95% |
| Reference | [1] Kikuchi S, et al. Cancer Res (2024) 84 (7_Supplement): ND11. |
