For research use only. Not for therapeutic Use.
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. W1131 inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU (HY-90006). W1131 regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway[1].
| Catalog Number | I040301 |
| Synonyms | 5-nitro-N-[4-[7-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]furan-2-carboxamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C25H20F3N5O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H19N5O4.C2HF3O2/c29-23(20-5-6-22(32-20)28(30)31)26-18-3-1-16(2-4-18)19-14-25-21-13-17(9-12-27(19)21)15-7-10-24-11-8-15;3-2(4,5)1(6)7/h1-7,9,12-14,24H,8,10-11H2,(H,26,29);(H,6,7) |
| InChIKey | CTRNPGALIMEDJQ-UHFFFAOYSA-N |
| SMILES | C1CNCC=C1C2=CC3=NC=C(N3C=C2)C4=CC=C(C=C4)NC(=O)C5=CC=C(O5)[N+](=O)[O-].C(=O)(C(F)(F)F)O |
| Reference | [1]. Ouyang S, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022 Jun;52:102317. |
