W146 (trifluoroacetate salt)

• CAT Number: R026441
• CAS Number: 909725-62-8
• Molecular Formula: C16H27N2O4P • CF3COOH
• Molecular Weight: 456.40
• Purity: ≥95%
• Synonyms: [3R-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)
• Storage: -20°C
• IUPAC Name: [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C16H27N2O4P.C2HF3O2/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;3-2(4,5)1(6)7/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);(H,6,7)/t15-;/m1./s1
• InChIKey: JDWCNCPWPLHFEX-XFULWGLBSA-N
• SMILES: CCCCCCC1=CC(=CC=C1)NC(=O)[C@@H](CCP(=O)(O)O)N.C(=O)(C(F)(F)F)O

W146 (trifluoroacetate salt)（Cat No.:R026441）is a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1P1), a critical receptor involved in regulating immune cell trafficking and vascular stability. By blocking S1P1, W146 inhibits the signaling pathways that modulate lymphocyte migration and endothelial integrity, making it a valuable tool in research focused on immune system disorders, inflammation, and vascular biology. It is particularly studied for its potential in autoimmune diseases like multiple sclerosis and other conditions where S1P1 signaling plays a key role in disease progression and immune response modulation.

Reference

1.Takuwa, Y.,Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. Journal of Biochemistry 131, 767-771 (2002).