For research use only. Not for therapeutic Use.
R-enantiomer of WAY-100135 (Axon 1360), a highly selective serotonin 5-HT1A antagonist. Its opposite enantiomer, (S)-WAY100135 (Axon 1341) is also available
| Catalog Number | I047537 |
| CAS Number | 149007-53-4 |
| Molecular Formula | C24H33N3O2.2HCl |
| Purity | ≥95% |
| IUPAC Name | (2R)-N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide;dihydrochloride |
| InChI | InChI=1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H/t20-;;/m0../s1 |
| SMILES | CC(C)(C)NC(=O)[C@@H](CN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3.Cl.Cl |
| Reference | K Wedzony et al. WAY 100135, an Antagonist of 5-HT1A Serotonin Receptors, Attenuates Psychotomimetic Effects of MK-801. Neuropsychopharmacology 2000, 23, 547-559.
KF Rhodes et al. The antagonist actions of WAY 100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1993, 348(3), 225-227.
NA Escandon et al. Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 1994, 268, 441-447. |
