WAY 213613

• CAT Number: I010599
• CAS Number: 868359-05-1
• Molecular Formula: C16H13BrF2N2O4
• Molecular Weight: 415.191
• Purity: ≥95%
• Synonyms: N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
• Target: EAAT
• Solubility: Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
• InChI: InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1
• InChIKey: BNYDDAAZMBUFRG-ZDUSSCGKSA-N
• SMILES: C1=CC(=CC=C1NC(=O)CC(C(=O)O)N)OC2=CC(=C(C=C2Br)F)F

WAY 213613(CAT: I010599) is a potent and non-substrate inhibitor of the excitatory amino acid transporter 2 (EAAT2), also known as GLT-1 (glutamate transporter 1). EAAT2 is responsible for the reuptake of the neurotransmitter glutamate from the synaptic cleft, thus regulating its concentration and maintaining normal neurotransmission. By inhibiting EAAT2, WAY 213613 can modulate glutamate levels in the brain. This compound has been studied for its potential therapeutic applications in neurodegenerative disorders and neurological conditions associated with altered glutamate signaling.