For research use only. Not for therapeutic Use.
WAY-362450（Cat No.:I004371）is a potent and selective antagonist of the farnesoid X receptor (FXR), a nuclear receptor involved in bile acid regulation, lipid metabolism, and glucose homeostasis. By inhibiting FXR, WAY-362450 has been studied for its potential therapeutic applications in metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and diabetes. FXR plays a crucial role in bile acid homeostasis and cholesterol metabolism, and antagonists like WAY-362450 are valuable in research aimed at understanding and modulating these metabolic pathways for therapeutic benefit.
| Catalog Number | I004371 |
| CAS Number | 629664-81-9 |
| Synonyms | propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate |
| Molecular Formula | C25H24F2N2O3 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO: ≤ 15 mg/mL |
| Storage | room temp |
| IC50 | 4 nM (EC50) |
| IUPAC Name | propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate |
| InChI | InChI=1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3 |
| InChIKey | INASOKQDNHHMRE-UHFFFAOYSA-N |
| SMILES | CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F |
| Reference | </br>1:Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. Zhang S, Wang J, Liu Q, Harnish DC.J Hepatol. 2009 Aug;51(2):380-8. doi: 10.1016/j.jhep.2009.03.025. Epub 2009 May 18. PMID: 19501927 </br>2:Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). Flatt B, Martin R, Wang TL, Mahaney P, Murphy B, Gu XH, Foster P, Li J, Pircher P, Petrowski M, Schulman I, Westin S, Wrobel J, Yan G, Bischoff E, Daige C, Mohan R.J Med Chem. 2009 Feb 26;52(4):904-7. doi: 10.1021/jm8014124. PMID: 19159286 |
