WAY-362450

For research use only. Not for therapeutic Use.

  • CAT Number: I004371
  • CAS Number: 629664-81-9
  • Molecular Formula: C25H24F2N2O3
  • Molecular Weight: 438.48
  • Purity: ≥95%
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WAY-362450(Cat No.:I004371)is a potent and selective antagonist of the farnesoid X receptor (FXR), a nuclear receptor involved in bile acid regulation, lipid metabolism, and glucose homeostasis. By inhibiting FXR, WAY-362450 has been studied for its potential therapeutic applications in metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and diabetes. FXR plays a crucial role in bile acid homeostasis and cholesterol metabolism, and antagonists like WAY-362450 are valuable in research aimed at understanding and modulating these metabolic pathways for therapeutic benefit.


Catalog Number I004371
CAS Number 629664-81-9
Synonyms

propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate

Molecular Formula C25H24F2N2O3
Purity ≥95%
Target FXR
Solubility DMSO: ≤ 15 mg/mL
Storage room temp
IC50 4 nM (EC50)
IUPAC Name propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate
InChI InChI=1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3
InChIKey INASOKQDNHHMRE-UHFFFAOYSA-N
SMILES CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F
Reference

</br>1:Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. Zhang S, Wang J, Liu Q, Harnish DC.J Hepatol. 2009 Aug;51(2):380-8. doi: 10.1016/j.jhep.2009.03.025. Epub 2009 May 18. PMID: 19501927 </br>2:Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). Flatt B, Martin R, Wang TL, Mahaney P, Murphy B, Gu XH, Foster P, Li J, Pircher P, Petrowski M, Schulman I, Westin S, Wrobel J, Yan G, Bischoff E, Daige C, Mohan R.J Med Chem. 2009 Feb 26;52(4):904-7. doi: 10.1021/jm8014124. PMID: 19159286

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