WD6305 TFA

• CAT Number: I040040
• Molecular Formula: C63H76F5N11O7S
• Molecular Weight: 1226.40
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[5-[4-[[[6-[4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-2-oxo-1,4,9-triazaspiro[5.5]undecan-9-yl]pyrimidin-4-yl]amino]methyl]phenyl]pent-4-ynoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C61H75F2N11O5S.C2HF3O2/c1-39(43-16-18-44(19-17-43)55-40(2)67-38-80-55)68-57(78)50-29-46(75)34-74(50)58(79)56(59(3,4)5)69-53(76)11-9-8-10-41-12-14-42(15-13-41)32-64-51-31-52(66-37-65-51)72-26-22-61(23-27-72)36-73(35-54(77)70-61)49-30-47(62)45(28-48(49)63)33-71-24-20-60(6,7)21-25-71;3-2(4,5)1(6)7/h12-19,28,30-31,37-39,46,50,56,75H,9,11,20-27,29,32-36H2,1-7H3,(H,68,78)(H,69,76)(H,70,77)(H,64,65,66);(H,6,7)/t39-,46+,50-,56+;/m0./s1
• InChIKey: BCCCNXZKLQWFCF-SCGGALBRSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCC#CC4=CC=C(C=C4)CNC5=CC(=NC=N5)N6CCC7(CC6)CN(CC(=O)N7)C8=C(C=C(C(=C8)F)CN9CCC(CC9)(C)C)F)O.C(=O)(C(F)(F)F)O

WD6305 TFA (Cat No.: I040040) is a trifluoroacetate salt form of a small-molecule compound used in cancer and metabolic disease research. It is known for its potential in modulating key cellular pathways, including apoptosis, signal transduction, and metabolic regulation. WD6305 TFA is utilized in in vitro and in vivo studies to investigate targeted therapy mechanisms and drug resistance. The TFA salt enhances its solubility and stability, making it a valuable tool in drug discovery and the development of novel therapeutic strategies.

Reference

[1]. Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456(23)00439-7
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