WDR5-IN-5

• CAT Number: I043324
• CAS Number: 2417012-26-9
• Molecular Formula: C29H29F3N6O
• Molecular Weight: 534.58
• Purity: ≥95%
• Synonyms: 2-[(S)-cyclopropyl-(4-methylpyridin-2-yl)methyl]-5-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-7-(imidazol-1-ylmethyl)-3,4-dihydroisoquinolin-1-one
• InChI: InChI=1S/C29H29F3N6O/c1-3-37-16-24(27(35-37)29(30,31)32)22-13-19(15-36-11-9-33-17-36)14-23-21(22)7-10-38(28(23)39)26(20-4-5-20)25-12-18(2)6-8-34-25/h6,8-9,11-14,16-17,20,26H,3-5,7,10,15H2,1-2H3/t26-/m0/s1
• InChIKey: FFUQRXFVTVBZMZ-SANMLTNESA-N
• SMILES: CCN1C=C(C(=N1)C(F)(F)F)C2=C3CCN(C(=O)C3=CC(=C2)CN4C=CN=C4)[C@@H](C5CC5)C6=NC=CC(=C6)C

WDR5-IN-5（Cat No.:I043324）is a small-molecule inhibitor targeting the WD repeat domain 5 (WDR5) protein, which plays a key role in regulating chromatin modification and gene expression. By inhibiting WDR5, this compound disrupts the function of protein complexes involved in the transcriptional activation of oncogenes, offering potential therapeutic benefits in cancer research. WDR5-IN-5 has shown promise in preclinical studies, particularly for targeting cancers with aberrant epigenetic regulation. Its ability to modulate gene expression pathways positions it as a potential candidate for cancer therapies, especially in the context of leukemia and other malignancies.