WDR5-IN-6

• CAT Number: I041058
• CAS Number: 326901-92-2
• Molecular Formula: C13H8Cl2N2O2S
• Molecular Weight: 327.19
• Purity: ≥95%
• Synonyms: 1-(2,5-dichlorophenyl)sulfonylbenzimidazole
• InChI: InChI=1S/C13H8Cl2N2O2S/c14-9-5-6-10(15)13(7-9)20(18,19)17-8-16-11-3-1-2-4-12(11)17/h1-8H
• InChIKey: PXUHMEZESKEPKJ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=CN2S(=O)(=O)C3=C(C=CC(=C3)Cl)Cl

WDR5-IN-6（Cat No.:I041058）is a small molecule inhibitor targeting WDR5 (WD repeat domain 5), a key protein involved in the regulation of gene expression through its interaction with histone methyltransferase complexes. By disrupting the WDR5-MLL (mixed-lineage leukemia) complex, WDR5-IN-6 effectively inhibits the aberrant gene expression associated with various cancers, particularly leukemia and solid tumors. This inhibitor has shown potential in preclinical studies for its ability to reduce tumor cell proliferation and induce cell death, making it a promising candidate in cancer research and therapeutic development.