WDR5-IN-6

• CAT Number: I041058
• CAS Number: 326901-92-2
• Molecular Formula: C13H8Cl2N2O2S
• Molecular Weight: 327.19
• Purity: ≥95%
• Synonyms: 1-(2,5-dichlorophenyl)sulfonylbenzimidazole
• InChI: InChI=1S/C13H8Cl2N2O2S/c14-9-5-6-10(15)13(7-9)20(18,19)17-8-16-11-3-1-2-4-12(11)17/h1-8H
• InChIKey: PXUHMEZESKEPKJ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=CN2S(=O)(=O)C3=C(C=CC(=C3)Cl)Cl

WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 (HY-16993), a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma[1].
WDR5-IN-6 (compound 19) inhibits the proliferation of IMR32 and LAN5 cells with EC50 values of 12.34 and 14.89 μM, respectively. WDR5-IN-6 shows moderate inhibitory effect on SK-N-AS cells, without effect on HEK293T cells at 20 μM[1].

Reference

[1]. Han QL, et al. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol Sin. 2023 Apr;44(4):877-887.
 [Content Brief]